The CDCâs Advisory Committee on Immunization Practices (ACIP) and the American Academy
of Pediatrics (AAP) recommend annual influenza vaccination for all children aged six months to 18 years. The National Asthma Education and Prevention Program (3rd revision) also recommends annual flu vaccination of asthmatic children older than six months.
In order to determine whether the vaccine was effective in reducing the number of
hospitalizations that all children, and especially the ones with asthma, faced over eight consecutive flu
seasons, the researchers conducted a cohort study of 263 children who were evaluated at the Mayo Clinic in Minnesota from six months to 18 years of age, each of whom had had laboratory-confirmed influenza between 1996 to 2006. The investigators determined who had and had not received the flu vaccine, their asthma status and who did and did not require hospitalization. Records were reviewed for each subject with influenza-related illness for flu vaccination preceding the illness and hospitalization during that illness.
They found that children who had received the flu vaccine had three times the risk of
hospitalization, as compared to children who had not received the vaccine. In asthmatic children, there
was a significantly higher risk of hospitalization in subjects who received the TIV, as compared to those
who did not (p= 0.006). But no other measured factorsâ"such as insurance plans or severity of asthmaâ"appeared to affect risk of hospitalization.